FRONTAL LOBE DYSFUNCTION IN PARKINSON'S DISEASE
Identifieur interne : 002951 ( Main/Exploration ); précédent : 002950; suivant : 002952FRONTAL LOBE DYSFUNCTION IN PARKINSON'S DISEASE
Auteurs : Ann E. Taylor [Canada] ; J. A. Saint-Cyr [Canada] ; A. E. Lang [Canada]Source :
- Brain [ 0006-8950 ] ; 1986-10.
Abstract
SUMMARY This study investigates the hypothesis that, as a consequence of Parkinson's disease, disturbed caudate outflow will lead to deficits in cognitive functions dependent upon the integrity of the prefrontal cortex, the cortical focus of caudatofugal signals. Since Parkinson's disease also involves lesions in extrastriatal midbrain cells which reduce the extrinsic supply of dopamine to this cortical region, such functions are at double risk. Forty nondemented parkinsonian patients were drawn from a pool of 100 consecutive patients and matched with 40 normal control subjects according to age, education, IQ, and sex. All patients were quantitatively rated on neurological indices of disease Neuropsychological assessment of the patient and normal groups included tests of general intelligence, psychomotor skills, memory, visuospatial and executive functions. No global cognitive decline was observed in the parkinsonian group. Moreover, memory and visuospatial abilities were generally intact. A small cluster of deficits emerged, interpreted as reflecting impairment in the ability to spontaneously generate efficient strategies when relying on self-directed task-specific planning. In addition, several tests thought to be sensitive to frontal lobe function distinguished patients with symptoms strongly lateralized to the right versus left side of the body. Deficits in strategic planning were later investigated in relation to severity of disease and to patient attributes including IQ and age, both of which were relevant to performance on specific tasks. Results were compared with previous investigations in parkinsonian patients and discussed from the perspective of both animal and human studies involving damage to the cerebral cortex and basal ganglia. As the prefrontal cortex is thought to play a crucial role in self-directed behavioural planning, the validity of an outflow model in predicting the consequences of caudate nucleus dysfunction was supported.
Url:
DOI: 10.1093/brain/109.5.845
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Lang</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C382AA4415104FFCC927E7E8CC744493C1471E1D</idno><date when="1986" year="1986">1986</date><idno type="doi">10.1093/brain/109.5.845</idno><idno type="url">https://api.istex.fr/document/C382AA4415104FFCC927E7E8CC744493C1471E1D/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000F62</idno><idno type="wicri:Area/Main/Curation">000D80</idno><idno type="wicri:Area/Main/Exploration">002951</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">FRONTAL LOBE DYSFUNCTION IN PARKINSON'S DISEASE</title><author><name sortKey="Taylor, Ann E" sort="Taylor, Ann E" uniqKey="Taylor A" first="Ann E." last="Taylor">Ann E. Taylor</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Psychology and Medicine, Division of Neurology and Playfair Neuroscience Unit, Toronto Western Hospital, Toronto, Ontario, Canada, Toronto, Ontario, Canada, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Saint Cyr, J A" sort="Saint Cyr, J A" uniqKey="Saint Cyr J" first="J. A." last="Saint-Cyr">J. A. Saint-Cyr</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Psychology and Medicine, Division of Neurology and Playfair Neuroscience Unit, Toronto Western Hospital, Toronto, Ontario, Canada, Toronto, Ontario, Canada, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Psychology and Medicine, Division of Neurology and Playfair Neuroscience Unit, Toronto Western Hospital, Toronto, Ontario, Canada, Toronto, Ontario, Canada, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1986-10">1986-10</date><biblScope unit="volume">109</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="845">845</biblScope><biblScope unit="page" to="883">883</biblScope></imprint><idno type="ISSN">0006-8950</idno></series><idno type="istex">C382AA4415104FFCC927E7E8CC744493C1471E1D</idno><idno type="DOI">10.1093/brain/109.5.845</idno><idno type="ArticleID">109.5.845</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">SUMMARY This study investigates the hypothesis that, as a consequence of Parkinson's disease, disturbed caudate outflow will lead to deficits in cognitive functions dependent upon the integrity of the prefrontal cortex, the cortical focus of caudatofugal signals. Since Parkinson's disease also involves lesions in extrastriatal midbrain cells which reduce the extrinsic supply of dopamine to this cortical region, such functions are at double risk. Forty nondemented parkinsonian patients were drawn from a pool of 100 consecutive patients and matched with 40 normal control subjects according to age, education, IQ, and sex. All patients were quantitatively rated on neurological indices of disease Neuropsychological assessment of the patient and normal groups included tests of general intelligence, psychomotor skills, memory, visuospatial and executive functions. No global cognitive decline was observed in the parkinsonian group. Moreover, memory and visuospatial abilities were generally intact. A small cluster of deficits emerged, interpreted as reflecting impairment in the ability to spontaneously generate efficient strategies when relying on self-directed task-specific planning. In addition, several tests thought to be sensitive to frontal lobe function distinguished patients with symptoms strongly lateralized to the right versus left side of the body. Deficits in strategic planning were later investigated in relation to severity of disease and to patient attributes including IQ and age, both of which were relevant to performance on specific tasks. Results were compared with previous investigations in parkinsonian patients and discussed from the perspective of both animal and human studies involving damage to the cerebral cortex and basal ganglia. As the prefrontal cortex is thought to play a crucial role in self-directed behavioural planning, the validity of an outflow model in predicting the consequences of caudate nucleus dysfunction was supported.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Taylor, Ann E" sort="Taylor, Ann E" uniqKey="Taylor A" first="Ann E." last="Taylor">Ann E. Taylor</name></noRegion><name sortKey="Lang, A E" sort="Lang, A E" uniqKey="Lang A" first="A. E." last="Lang">A. E. Lang</name><name sortKey="Saint Cyr, J A" sort="Saint Cyr, J A" uniqKey="Saint Cyr J" first="J. A." last="Saint-Cyr">J. A. Saint-Cyr</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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